The phenothiazines prochlorperazine Compazine and chlorpromazine Thorazine have been shown to reduce nausea and vomiting of pregnancy compared with placebo. The addition of promethazine to morphine was associated with a significant decrease in the symptom-therapy score for nausea. Additional limitations are the low or limited number of patients available for analysis, the recruitment of only women, and the non-existence of placebo groups in some studies.
There was no difference in efficacy between 6.
This article will review the therapeutic efficacy of promethazine in the treatment of postoperative nausea and vomiting. Acta Anaesthesiol Scand ;48 5: Comparison of the antiemetics metoclopramide and promethazine in labour. Promethazine was once sold under the brand name Phenergan but is now available as a generic.
Anesthesiology ;91 3: The authors alone are responsible for the views expressed in this publication and they do not necessarily represent the decisions or policies of the World Health Organization.
Carlisle J, Stevenson C and . Doubleblind comparison of granisetron, promethazine, or a combination of both for the prevention of postoperative nausea and vomiting in females undergoing outpatient laparoscopies.
The average adult dose for amelioration of allergic reactions to blood or plasma is 25 mg. The use of simple ketamine anaesthesia for day-case diagnostic laparoscopy.
Administration of promethazine pre- or post- operatively reduced PONV and the number of patients asking for rescue antiemetic on postoperative day 1, as compared with Control group.
The assessment of nausea and vomiting. The combination of promethazine and atropine was very effective in reducing occurrence of PONV. Healthcare providers need to monitor patients for phlebitis, blistering, swelling, and for burning or pain at sibutramine price injection site.
However, one investigator 22 warned that ginger root contains thromboxane synthetase inhibitor, which may interfere with testosterone receptor binding in the fetus.
Promethazine prescribing label information. Anesth Analg ;91 5:
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The review which included the most clinical trials evaluating the effectiveness of promethazine was a Cochrane systematic review.
Control group — received normal saline There were significant differences regarding nausea, vomiting, and patients who asked for antiemetic at the first h and h after surgery between group 3 and groups 1 and 2. AANA J ;77 4: Promethazine was once sold under the brand name Phenergan but is now available as a generic.
If treatment with prochlorperazine or promethazine is unsuccessful, some physicians try other antiemetics, such as trimethobenzamide Tigan or ondansetron Zofran and .
Curr Pharm Des ;11 Due to the heterogeneity of the retrieved clinical trials, it was not possible to pool the data in a meta-analysis as no common or unique outcome could be determined.
The development and validation of a risk score to predict the probability of postoperative vomiting in pediatric patients. One clinical trial included 87 patients aged 13 — 72 years, but we were unable to identify the exact number of participants that were under or over 16 years from the published data.
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